I am not sure when this happened, or how it happened, but there is a glitch with the Input/output connections on the PLC.
Nature of the Bug is as follows:
The left side of the PLC, while it appears to connect wires, does not appear to accept signals.
// ADDENDUM
I was looking at Useful Map Colors as the culprit after disabling them cleared the issue. But checking their mod's update version, I got suspicious considering the last update was months ago. Doing a reenable test to confirm if it was causing trouble shows the PLCs to work fine now.
My only other theory at this time is either that having my game up running constantly janks with PLCs, or that a multiplayer game issue messed them up. I did have a friend experience a Desync out of nowhere earlier today.
Only recommendation at this time: Total game closeout to desktop, followed by complete restart.