I am not sure if its just me, but I have lag spikes when I have expanded rocket payloads with other mods. I don't know if I get lag spikes if its by itself. I haven't try to yet. here is the mod list I have:
Aircraft
Better Power Armor Grid
BigBags
CanalBuilder
EvoGUI
FNEI
FactorioExtended
MaxRateCalculator
More Equipments Mod
More Exoskeletons
Personal Roboport mk3
spacemod
more Fusion Reactors
ore eraser
rso mod
upgrade planner
I am not sure if this place to put this.