loading and saving problems for me started after upgrading factorio from 0.18.19 to 0.18.21 and many mods too. thus i don't know whether the base game causes this, or this mod, or another unknown mod, but because of the time to update the road network, i would assume that there are some really huge data structures involved, and it's not only the autosave taking much(!) longer, but also that the savegame size is more than three times as big as before :
loading my old autosave the first time took maybe FIVE MINUTES. then the game showed some migration of the base game (lots of demo-researches removed), and this mod also showed that updating the road network had taken 107000 ms (107 seconds).
edit: when loading that old save again (for testing), the time used was 131000 ms (more than 2 minutes).
doing an autosave which before had taken several (<5) seconds now takes almost THREE MINUTES (to be exact something around 2:50), and when looking at the savefiles, the old savefiles were only a bit over 11 MB, and the new savefiles are more than 35 MB.
i didn't try yet to enable/disable different sets of mods (my mod list is as long as Illyria's list, but most mods are different and only maybe 15 are included in his list too), but first looked into discussions and post this as reply to someone "definitively" having found that this mod may cause the increased load/save times.
edit: after disabling this mod, the migration and the load and save times are back to normal (a minute for migrating factorio, <5 sec to load/save maps), but of course with so much from this mod gone, it would be unusable now.
ps: since i play without bots and only relatively short belts (2.2k belts to connect 100 request depots and 45 provider depots to many local setups/rows of assemblers) and most roads are two tiles wide, my road network has almost 2000 road tiles ... this should be considered only a minor size for factories (I'm just about to build a bigger oil factory to replace my old one that barely produces petroleum so that i could research and build power armor to fight biters in front of the next oil field :-) until i launch a rocket, the road network will probably grow to at least triple this size, and then cause autosaves to take 100+MB and 9 minutes ??