Hey,
i was really excited as a saw one of my favorite mods proted to 0.16.
Sadly at the moment it has no use whatsoever as changing any checkbox doesn't do anything. As soon as I close the Lokomotive Window and open it again, all my Settings are gone.
But, I can still create a line, the train I created it with will be shown as active, but then, i can't uncheck the active checkbox.

All experienced on 16.12, running on a headless server.

I'm having the same problem, in a single player map. Its like it doesn't update when you check a box, which kinda defeats the purpose of the whole thing

Also having the same issue. None of the settings save and i am having to manually refuel the trains or add the refuel station as a stop.

As a hotfix you can add one line into control.lua

after (line 1724 in v 2.2.0)
script.on_event(defines.events.on_gui_click, on_gui_click.on_gui_click)

add
script.on_event(defines.events.on_gui_checked_state_changed, on_gui_click.on_gui_click)

This is caused by fa 0.16 gui changes