Want to add my opinion on this topic.
I really like this idea. Wondering, why it has like <100 downloads for now. The whole concept of naturally generated areas, which player can use to his advantage, but can't move wherever he wants is really good and i can agree with previous speaker, this i what factorio lacks of.
I think this whole thing can be expanded to apply more interactions besides just "using/avoiding".
What i also think of, player should have the ability to destroy crystals, but that shouldn't be easy. Just removing it like rock or destroing by shooting is out of option. It would be interesting to create some building, which can mine the crystal for several seconds (for example), but it also ulocks somewhere after green/blue packs, takes bunch of energy/lubricant/some other resource. So pllyer still need to ajust it's buildings most of the game, but it's still not some insurmountable obstacle.
Also, Threre would be pretty interesting interaction, if player can "infuse" crystals, changing it's properties. Just some basic idea: any crystal can be destroyed (like on previous part, not just picked up) to get different shards. These shards can be used in tech (independent lab just for shards or their derivatives)/resource/machines, which then can be then used to interact with other crystals. Like, you need 4 "Infusers", place them around crystal, give energy ans specific item. By doing that you can either change the size of affected area, change type of crystal to another (maybe not so good idea, because it kinda breaks the rule of "take what the world gives you"), make it stronger, convert to "Industrial crystal", so it needs energy or conctsnat supply of some resource to give stronger bonuses.
But it still, player can not move crystals, build it's own ones etc.
Maybe some strange interactions, like while destroing/infusing some activities whithin a radius of that process can take the role of catalists: biters being close enough/entity taking damage from fire/fast moving vehicles of any type (build loop of rails to speed up the process/make it less expensive/give extra bonus).
Probably some passive interactions which just happen and deal with it.
I don't know, what is possible and what not, but i think this mod has huge source of interesting features.