My game was freezing periodically and I found that the cause was this mod.
I even opened a thread on the official game forum: https://forums.factorio.com/viewtopic.php?f=49&t=89942
The problem also goes away if I remove the signs I was using: "Mark items on ground", "Deconstruct finish miners" and "Find all the fish".

Thanks.

Can you post the save so I can diagnose it

Saved Game and Mod List: https://www.file-upload.com/?op=upload_result&st=OK&fn=qn3y4qj1jck1&st=OK&fn=qkkcs01723nh

My game is heavily modded! If you want, I can send my entire game profile. I think this would be easy to test.

To reproduce the problem, start walking with the character for about 1 minute. Every 1 minute or so this mod will perform some action and the game will freeze for a brief period (less than 1 second), but it is enough to be a little annoying.

Thanks.

I imagine it's the mod processing something related to depleated mines, droped items or fish!
I have not changed any default mod settings about time of updates, cicles, rate, etc... Maybe some of that settings can improve the behavior of the game.

Thanks.