Pollution will cause sea level rise and desertification. Be careful that your factory does not destroy the entire planet.
Mods introducing new content into the game.
Map generation and terrain modification.
I don't want to completely shut down the Bitter threat.
Does your mod avoid adding the water tiles close to spawners, so that Bitters can still spawn.
I am using the Canal Builder mod so Players, vehicles, and biters can cross shallow water. This I hope will keep Bitters attacking me.