I've recently discovered a mod called Shortwave that allows to transfer signals bidirectionally and in real-time (with no on_tick) without any additional performance cost.
Apparently, it uses two decider combinators that are connected with invisible green/red wire pair. What's even more interesting, is that combinators can be connected across surfaces using LuaEntity.connect_neighbour.
Implementing something similar in Factorissimo2 would enable real-time, more efficient and more convenient factory circuit connections.