There are massive lag spikes every ~10 seconds. This is on a world with no roboports yet. It is possible there is a mod conflict, as I'm doing an AngelBob run.
I ran into the same issue (lag spikes, AngelBob) but I kept the mod. The issue immediately went away once a roboport was built, and returned when I removed it.
Starting having big spikes after my entire base was covered. I made a video with the 'show-time-usage' diagnostics up and confirmed that the delay is caused by ConcreepRefined, update took 107 seconds.
The issue seems related to having no places to place concrete since it's apparently also present when there's no roboports.
Ok so I believe this is also Factorio being itself, seems that if you just blueprint a bunch of concrete and place it in an empty ar______ea- oh sorry, had a lag spike. It's consistently replicateable for me at least, and you don't notice it as much if you wave around, but if you place the ghost tiles all at once it happens, and it's kind of bad.
Best thing I could respond with then is to either reduce the query rate or how much of the bot network it can use at once. That should calm things a bit.