If the Quickbar is not enough, create toolbars that can hold items and tools and be positioned anywhere you like.
Providing the player with new tools or adjusting the game interface, without fundamentally changing gameplay.
Can you do the same thing for the shortcut keys? That would be greatly appreciated.
Currently I don't see possibility to do that in Factorio API, I couldn't find a way to trigger shortcut action. But Toolbar supports tools from shortcuts so it shortens shortcuts greatly in my case.