I've noticed the drones will sometimes be inactive upon reentering a save. the quick fix is to pick them up and place them back down. See if that resolves it, it's not a fix, but it definitely narrows the scope of the bug.
It happens to me sometimes, but in my save it is very rare, I will try to optimize it.
Sometimes the Companios look little lazy, as there is some lage before they start the work.