The nests are inert and only trigger to make biters when destroyed. They are enemy so defences and your own weapons will target them.
The mod was made for a specific community multiplayer map that was player over Easter as a bit of random fun. Time constraints lead it to not be developed as much as it could have been. Example of the mod being used with other mods to make the map different: https://youtu.be/a8lY8fWGG6I?t=375