I may have the math wrong here so correct me if im wrong (there is SO much abstraction with recipe based math) but my rough calculations tell me that you need 5 breeder reactors to support about 3 MOX reactors, i think 15:10 is the more accurate ratio if you're going for closed cycle that is, though you will have TONS of pu 238 more so if you reprocess used MOX. Now im playing with numerous mods, and currently im able to convert uranium to neptunium, and then to pu239 so the lack of accessible plutonium isnt a huge issue, but thats not PE doing that (at least i dont think so). Either, the breeder cell recipes should align nicely with the MOX fuel recipes or there should be some method to get rid of excess pu238 other than ammo obviously. That and perhaps breeder reactors should burn more fuel, they're monumentally slow as is. Similar reactors IRL can burn much much hotter. That would be a fairly simple buff to implement.
One lazy option is just keeping enrichment but making it take AGES, with the mods im playing with kovarex takes 2100 seconds to complete which is an absolute pain, forces you to optimize your fuel cycle or have insane kovarex production and handling. In order to support a 1.1gw 8 reactor plant off of kovarex alone you need upwards of 220 centrifuges running near constantly. Its basically the same physical size as a 1.1gw plant and makes it a mess to deal with (each centrifuge stores like 80 uranium unless you run circuit conditions on all of them)
As a nuclear nerd myself i understand the want for realism, but lets be honest, storing hundreds of thousands of u238 and pu238 just aren't interesting or practical for factorio, especially considering the life span of fuel cells. Refueling only needs to happen once a year at most in real reactors. I think there are a few that run shorter cycles but those aren't for power generation afaik.