I have reproduced this, the game itself (not my mod) just lags with all the Biter combat between very large nests, as you get out further away from spawn. My advice is don't explore so fast.. or I can add an option to 'infect % biters with death plague" in the mod options, so not only will it randomize their faction for each chunk but also randomly kill a % of them at the same time, to reduce the quantity of massive battles and hopefully keep your CPU and UPS okay. Does that sound okay?