I'm almost to the Rocket in my playthrough and enjoying your mod very much so far. It really changes up the gameplay to something new.
The item I miss the most is a 'long heat inserter'. You can barely use heat inserters, because most of my assembler setups have a fast and a long side by side, and that stops the flow of heat at the moment. I guess it becomes more practical with assembler machine 3 because of the additional heat in/out, but it would be more comfortable if there was a long version of the inserter. It becomes more blueprint-friendly, if you don't have to worry about fuel.
Another thing I noticed in my playthrough is that I am insanely polution-efficient. The biters leave me completely alone. I think that, because energy production and thus polution is concentrated in the reactors, you could give them a significant increase in polution output. x10 doesn't sound too much to me.